Restylane Defyne


As the body ages, skin loses its elasticity and lines throughout the face become more and more pronounced. For millions of people across the world, these uncontrollable changes bring up real anxieties which can cripple confidence and self-image.

At the New Orleans Center for Aesthetics and Plastic Surgery, we believe in offering our patients something they can control, a wide range of choices both surgical and non-invasive to ensure you have the body, face, and skin of your dreams. No one deserves to feel anything less than beautiful, fresh, and ready to take on the world. We are very excited to offer Restylane Defyne, a treatment crafted with XpresHAn Technology®, to correct deep lines on the face.

Unlike many traditional age-reversing procedures, Restylane Defyne® is uniquely suited to help support your facial expressions and is the only non-invasive treatment proven to maintain motion and ease. You get the same considerable restorative effects and keep your natural motion all the while.

Restylane Defyne Logo


Nasolabial folds, which are the deep lines that go from the nose to the corners of the mouth, and marionette lines, or the deep lines that go from the corner of the mouth down to the chin, are difficult to treat. Let alone treat with natural results and minimal downtime.

With the arrival of Restylane Defyne, there is now a completely nonsurgical treatment specifically designed to treat deep wrinkles such as nasolabial folds.

woman looking intensely showing facial contours

With a treatment that involves only a few simple injections, Restylane Defyne can help you achieve subtle, natural rejuvenation that will last for up to 12 months. Restylane Defyne is a dermal filler, a smooth gel that’s injected into the treatment area such as nasolabial folds, to create volume under the skin to smooth out wrinkles.

Restylane Defyne only takes a few minutes to perform, is delivered using an incredibly small needle, and its formula includes lidocaine to help reduce any kind of discomfort. After a treatment, patients should be able to enjoy a smoother, more youthful appearance.


Restylane Defyne performs like no other filler, and the proof is clinical. In a multicenter, noncomparative trial study of patients aged 35-65 years, clinicians monitored the effectiveness of the treatment as well as the preservation of natural facial expressions after receiving Restylane Defyne.

  • 97% of patients were satisfied with their treatment results and said they would do the treatment again
  • 95% would recommend the product to a friend

Restylane Defyne is the only filler on the market that has been shown in a clinical study to help maintain movement and expressions.


Restylane Defyne was developed by Galderma: the company that created other great fillers such as: Restylane Lyft®, Restylane®, and Restylane Refyne®. This unique formula uses hyaluronic acid, a naturally occurring sugar found in the human body that binds and retains water molecules. Though new to the United States, Europeans have been experiencing the benefits of Restylane Defyne for several years under a different name.

Restylane Defyne is formulated using XpresHan Technology, which creates an advanced gel with the optimal combination of flexibility and support. XpresHan formulation allows the Hyaluronic Acid gel to flex and move inside the skin naturally with facial movement, allowing for subtler, natural results. However, Restylane Defyne is unique because its sturdy gel also allows for stronger structural support; in fact, Restylane Defyne was made for especially deep wrinkles, nasolabial folds and facial depressions. With its advanced gel formulation, you have the opportunity to get real results without the risk of looking overdone or unnatural.

When you arrive at our New Orleans office, our team of doctors can help to assess your anatomy, desired outcomes, and treatment or downtime preferences. There are a wide variety of fillers we offer such as Juvederm and a variety of Restylane products, each with their own unique results.

We are happy to discuss all your available options to guarantee you get the results you want when you want them. Once you have made your decision, we will come up with a unique treatment plan for your situation, and schedule any appointments necessary.

The administering of Restylane Defyne is comfortable, quick and easy. We will use very small needles to expertly perform a series of injections to ensure desired results. It will be quick and virtually painless, patients who do feel anything liken the feeling at worst to an insect bite.

Your Restylane Defyne treatment will be completely nonsurgical, so there is only a minimal recovery period required. You should see an immediate improvement after the treatment, but the full results should appear after a week. Some patients experience swelling, bruising, and tenderness in the treatment area, but these symptoms are only temporary and should go away after a week.

Dr. Velargo and Dr. Hendrick are both highly trained and experienced injectors, and can deliver Restylane Defyne with superior levels of artistry and safety.

One of the biggest benefits of Restylane Defyne is simply how long results last. Many of our patients report the positive effects lasting as long as 12 months after a single treatment.

If you wish to extend results beyond this, we are glad to schedule touch up procedures.

Restylane Defyne plays very well with other fillers and can be easily combined with different procedures in the same visit.

Restylane Defyne was formulated and developed to treat nasolabial folds (lines that run from the corners of the nose to the corners of the mouth). It works especially well in this area due to its formulation with XpressHAn technology, which gives greater support while maintaining more flexibility than other more traditional hyaluronic acid fillers.

But that’s not all! Restylane Defyne can be administered to treat other issues as well, such as marionette lines.

Most common side effects from Restylane Defyne are more likely to be associated with the injection process rather than the filler itself.

During the injection, a small needle penetrates your skin, which may elicit the body’s inflammatory response. Therefore, some patients experience slight redness and inflammation for 24-48 hours after treatment. These side effects, however, go away quickly and without trouble. If you are concerned about the appearance, make-up is a great way to address these issues and keep you out and about even immediately after a procedure.


Drs. Hendrick and Velargo are partners in the New Orleans Center for Aesthetics and Plastic Surgery and are happy to answer any of your questions when it comes to non-surgical age-reversing options. Don’t hesitate to reach out to our New Orleans office at 504-533-8848 today with your questions or schedule a one-time, no-obligation consultation.